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Off-label use of antipsychotics should be done cautiously in children


Children and young adults aged 5 years to 24 years who were prescribed higher doses of antipsychotics were found to be at a 1.8-times higher risk of death from any cause, 3.5-times higher risk of unexpected death not caused by an overdose, and a 4.29-higher risk of death due to cardiovascular (CV) or metabolic causes compared with those prescribed control medications, according to results of an observational study published in JAMA Psychiatry.


Ray WA, et al. Association of antipsychotic treatment with risk of unexpected death among children and youths. JAMA Psychiatry. 2018;[Epub ahead of print]. 

Geller B. Antipsychotics, excess deaths, and paradoxes of child psychiatry. JAMA Psychiatry. 2018;[Epub ahead of print].