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Antiepileptic drugs associated with serious skin reactions


The risk of serious adverse skin reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is increased with use of antiepileptic drugs (AEDs) compared with non-AEDs, with the highest risks observed with zonisamide, rufinamide (Banzel—Eisai), clorazepate, lamotrigine, phenytoin, and carbamazepine, according to a review of FDA’s Adverse Event Reporting System (FAERS) published in Epilepsia.