Drug Interactions Corner

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Common antibiotics do not appear to interact with hormonal contraceptives


Clinical and pharmacokinetic studies do not appear to support an interaction between hormonal contraceptives (HCs) and most nonrifamycin antibiotics (e.g., penicillins/cephalosporins, tetracyclines, fluoroquinolones, macrolides, and others), according to results of a systematic review of 29 studies published in the American Journal of Obstetrics and Gynecology.


Simmons KB, et al. Drug interactions between non-rifamycin antibiotics and hormonal contraception: A systematic review. Am J Obstet Gynecol. 2018;218(1):88–97.