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Early data show genotyping can predict response to antidepressants

KEY POINT

Genotyping data from 706 patients with moderate to severe depression in the GENDEP (Genome- Based Therapeutic Drugs for Depression) project showed a genome-wide significant association between marker rs2500535 in the uronyl 2-sulphotransferase (UST) gene and clinical response to nortriptyline, and a suggestive association between a marker in the interleukin-11 (IL11) gene and clinical response to escitalopram; larger genomewide studies are needed to confirm these preliminary findings.

SOURCES

Uher R, et al. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry. 2010;167:555–64.

Malhotra AK. The pharmacogenetics of depression: enter the GWAS [editorial]. Am J Psychiatry. 2010;167:493–5.