Psychiatry

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New analysis compares efficacy and safety of antidepressants

KEY POINT

Results of a systematic review and network meta-analysis involving 21 antidepressants (two not available in the United States) for acute treatment of adults with major depressive disorder (MDD) found all antidepressants to be more efficacious than placebo. Compared with placebo, only amitriptyline had significantly greater efficacy than some but not all of the other antidepressants. The analysis also did head-to-head comparisons and rated these medications on the basis of efficacy and acceptability.